A collodion baby is born with a tough, inelastic parchment-like membrane covering the whole body surface. As the membrane fissures and peels, a more characteristic ichthyosiform change is evident beneath the collodion membrane. Uncommonly, normal
skin
is found under it.
We herein present two cases of collodion baby, which were confirmed as a sporadic case of lamellar ichthyosis and a case of lamellar exfoliation of the newborn, respectively, after long-term clinical observation.
It is necessary that detailed genetical and molecular biological studies should be performed in order to elucidate the fundamental, molecular changes that cause these dramatic cutaneous changes. (Kor J Dermatol 1997;35(1) : 129∼134)
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